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Clinical research blog

Explore our blog for insights into the big questions in precision medicine and clinical research.

Podcast recap: Inigo Martincorena on somatic evolution in healthy tissue

Every cell in the body picks up changes to its DNA over a lifetime. For most of the history of cancer genomics, researchers could only read those changes once a...
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Genetic eligibility shows up earlier in the pipeline than most plans assume

During enrollment planning, genetic eligibility is often treated as a therapy area question, settled once a program knows which organ system it targets. Genetic...
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Podcast recap: Marleah Dean Kruzel on reframing hereditary cancer uncertainty

In the latest episode of The Genetics Podcast, Patrick sits down with Dr. Marleah Dean Kruzel, Professor of Communication at the University of South Florida. He...
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Podcast recap: Dave Hallett on cutting through the AI hype in drug discovery

In the most recent episode of The Genetics Podcast, Patrick Short sat down with Dr. Dave Hallett, Chief Scientific Officer at Recursion. Dave has spent nearly t...
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Podcast recap: Danny Miller on making long-read sequencing the first test every patient receives

Most patients with a suspected genetic condition still move through testing one layer at a time. A panel checks a set of genes, a separate assay looks for a rep...
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Podcast recap: Brent Richards on how genetic evidence can de-risk drug targets

In the latest episode of The Genetics Podcast, Patrick Short sits down with Dr. Brent Richards, CEO and founder of 5 Prime Sciences and Professor of Human Genet...
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Podcast recap: Andrew Jackson on how the same DNMT3A mutations behind dwarfism drive an accelerated aging syndrome

In the latest episode of The Genetics Podcast, Patrick Short speaks with Dr. Andrew Jackson, Programme Leader at the MRC Human Genetics Unit within the Universi...
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Podcast recap: Stevie Ringel on building operational capacity for rare disease drug development

Rare and ultra-rare disease research has produced real scientific breakthroughs over the past decade: antisense oligonucleotides, gene therapies, and gene editi...
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Why cell and gene therapy programs stall between protocol and patient

Cell and gene therapy has solved problems that seemed intractable a decade ago. The science of editing genomes, replacing defective genes, and engineering patie...
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Podcast recap: Jagesh Shah on why delivery is genetic medicine's real bottleneck

In genetic medicine, we increasingly know what to deliver. The unsolved problem is getting it to the right place in the body. That was the central thesis in the...
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