Natural history studies document disease progression by observing diseases in their unmodified state, deepening our understanding of how conditions evolve over time. In the drug development process, they serve as external comparators by providing baseline data against which treatment effects can be assessed. They act as fundamental benchmarks that inform trial design and evidence generation when randomized controls are impractical.
In the informative webinar hosted by Dr. Patrick Short, Co-founder and CEO of Sano Genetics, guest Dr. Andrea Gropman explored the profound impact of genetics and genomics on modern medical practice. The discussion provided valuable insights into the journey of translating genetic discoveries from the laboratory to the bedside, particularly focusing on neurogenetics and metabolic disorders.
Last week, Sano had the privilege of travelling to Boston for the Chief Medical Officer Summit 360°, where our Co-founder and COO, Charlotte Guzzo, shared her expertise on a panel focused on practical approaches to patient engagement. This event provided a platform for rich discussions on the shifting paradigms of drug development and precision medicine. Here, we’ll share an overview of key discussions and insights from the conference, emphasising the innovative strategies highlighted during the panels.
Natural history studies are instrumental in advancing precision medicine by offering a nuanced understanding of the patient journey across various diseases, including Duchenne Muscular Dystrophy, Spinal Muscular Atrophy, and Huntington's Disease. For rare diseases such as Duchenne Muscular Dystrophy, Spinal Muscular Atrophy, and Huntington's Disease, clinical trial design is constrained by small patient populations, limited disease characterization, and the absence of validated outcome measures.
This webinar, co-hosted by Sano Genetics and PrecisionLife, highlighted the complex nature of long Covid, which affects up to 30% of Covid-19 survivors and presents with more than 50 symptoms. The discussion brought to light the limitations of traditional genomic research, which has struggled to identify significant genetic risk factors, and underscored the necessity for innovative methodologies in understanding and treating this condition.
Liver disease remains one of the leading causes of morbidity and mortality worldwide, presenting complex challenges in healthcare due to its multifaceted nature and often silent progression. Advancements in genetic research have begun to illuminate the pathways through which liver diseases develop, revealing that conditions like metabolic dysfunction-associated steatohepatitis (MASH), previously known as nonalcoholic steatohepatitis (NASH), are not only influenced by lifestyle but also by genetic predispositions.
At Sano, our mission to accelerate the world’s transition to personalised medicine hinges on precise, individualised insights from vast amounts of health data. Understanding the sensitive nature of this data, we've committed to the highest standards of privacy and data protection, as detailed in our latest whitepaper, "Sano’s privacy promise."
This webinar focused on the potential of artificial intelligence (AI) in drug development, particularly within the realms of precision medicine. Hosted by Charlotte Guzzo, COO of Sano, the session featured insights from top industry experts who discussed their personal journeys at the intersection of technology and healthcare, the challenges of integrating AI into drug development, and the cutting-edge innovations their companies are pioneering.
In this webinar, Sano’s Senior Project Manager Clare Clarke shares the approach Sano employs to achieve its mission of accelerating the world’s transition to precision medicine. She outlines the seamless integration of recruitment, biomarker testing, and engagement within research trials, and provides an overview of Sano’s technology. This is the first in a series of webinars that will showcase various aspects of Sano’s product.
Many hereditary diseases are clinically manageable when detected early, yet most carriers are identified only after symptoms appear. Population genomic screening addresses this gap by testing large populations of otherwise healthy individuals to find genomic variants associated with clinically actionable conditions. These conditions can often be prevented or mitigated when detected early. By identifying individuals at risk of preventable and treatable conditions, screening directly reduces morbidity and mortality when results are acted upon.