Sano blog | protocol design

precision medicine protocol design population health health equity

The All of Us milestone shows precision medicine’s next infrastructure challenge

The NIH’s All of Us Research Program has become the world’s largest integrated genomic and electronic health record database. Its June 30 data release includes ...

screen failure protocol design

Reducing screen failure starts with better trial design

When a clinical trial misses its enrollment targets, the instinct is often to look at recruitment through more channels, more outreach, and a bigger advertising...

rare disease protocol design

Rethinking drug approval for ultra-rare disease: Inside the UK’s n-of-1 ASO trial

Last week, the rare disease field celebrated another breakthrough. A teenage girl with an ultra-rare genetic neurodegenerative disease was treated with a bespok...

precision medicine protocol design

Lessons from recent FDA actions in precision medicine

Over the past few years, several cell and gene therapies (CGTs) in precision medicine have received FDA Complete Response Letters (CRLs). As the agency increase...

Regulatory signals for precision medicine trial sponsors

rare disease protocol design

Top five regulatory signals sponsors can act on now

The FDA’s activity in 2025 reflected a mix of scientific progress and operational instability. Precision medicine programs benefitted from new draft guidance, r...

patient recruitment protocol design

Expediting study start-up: Best practices for sponsors

Study start-up is a critical stage of the drug development process and can have a major impact on trial timelines, budgets, and overall success. Start-up activi...

patient recruitment protocol design

Clinical trial budgeting: Smarter strategies for biotech

Clinical trials have always been burdensome on sponsors, but in the current biotech landscape, the pressure to execute trials promptly, efficiently, and in a co...

thought leadership protocol design

The future of AI in clinical research: A conversation with Sano’s CTO

At Sano Genetics, our mission is to deliver and facilitate clinical trials that accelerate the development of precision medicine treatments for patients. As a c...

precision medicine protocol design

Master protocols in precision medicine: Basket, umbrella, and platform trials explained

Precision medicine has fundamentally changed how diseases are defined and how therapies are developed — shifting eligibility from clinical phenotype to molecula...