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Clinical research blog

Explore our blog for insights into the big questions in precision medicine and clinical research.

The genetic crystal ball: How polygenic risk scores predict disease risk and guide drug discovery

While lifestyle choices and environment can impact risk, genes are often what most affect how likely a person is to develop a disease. People commonly have diff...
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CRISPR gene editing: Promise, risks, and regulation

CRISPR (clustered regularly interspaced short palindromic repeats) and CRISPR-associated (Cas) proteins were first characterized as part of bacterial immune def...
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Pharmacogenomics testing: Safer dosing and reduced ADR risk

Pharmacogenomics, also known as pharmacogenetics, is a field of research dedicated to investigating how an individual's genetic makeup influences their response...
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Phenotypic data: Why genetic data needs context in research

Genetic data is at the heart of precision medicine. Understanding the influence of genetics on health has helped us to identify risk factors for disease, predic...
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Drug target discovery: Genetic data to clinical trials

The success of any precision medicine program depends on the quality of the target it pursues. A well-validated genetic target shapes everything downstream: whi...
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VUS genetics in clinical trials: Managing uncertainty

When an individual undergoes genetic testing, they often expect to find definitive answers about their genes. However, around 20% of genetic tests identify vari...
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Patient registry: Benefits and risks for precision trial recruitment

A 2015 study published in Nature found that by harnessing genetic data to support the selection of candidate drugs, researchers could double their success rates...
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The genetic evidence advantage in drug development

In the ever-evolving world of healthcare and pharmaceuticals, researchers are constantly seeking ways to make drug development more efficient and effective. San...
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Genetic data sources for drug discovery teams

Genetic data is now central to how drugs are discovered, developed, and brought to patients. For teams designing precision medicine programs, understanding wher...
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Webinar recap: Ethical and regulatory landscapes in precision medicine

The rapidly evolving landscape of precision medicine has opened new avenues for personalised treatments, transforming how we approach patient care. Genetic info...
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