Download the free whitepaper: Unravelling the complexities of genomics-driven drug discovery

Genomics-driven drug discovery holds immense promise in developing targeted therapies by leveraging genetic and biomarker information to understand the root causes of diseases. However, the field faces significant hurdles.

In this whitepaper, we examine the obstacles of limited recontactability, scarcity of multi-omics data sets, lack of diversity in data, and the challenge of scaling research for rare diseases. By addressing these challenges and proposing strategies to address them, this whitepaper aims to chart a path by which we can harness the full potential of genomics-driven drug discovery.

 

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Early program playbook: Designing precision trials that don’t fall behind before FPI

Most early precision trials are shaped long before the first patient is enrolled. In the pre-FPI window, teams lock in eligibility criteria, biomarker strategies, endpoints, and data infrastructure under uncertainty and time pressure. These early decisions determine who can enroll, how signals are interpreted, and whether the program can adapt as new information emerges.

When early assumptions are not tested against real patients and real operational constraints, the consequences tend to surface later as slow enrollment, ambiguous results, protocol amendments, or stalled programs.

This playbook outlines the pre-FPI design decisions that have the greatest impact on early precision programs, including how to:

✅ Stress test translational evidence against real-world patient populations
✅ Define precision populations that are scientifically valid and operationally feasible
✅ Design biomarker strategies that scale beyond discovery settings
✅ Build learning and decision-making into early protocols
✅ Ensure data is ready when early insights are needed

Download the full guide to learn more about designing early precision trials that are built to learn, adapt, and move forward with clarity.

PBGroup