The development of NASH, the advanced stage of nonalcoholic fatty liver disease, is a complex interplay of genetic and environmental factors. Genes like PNPLA3, TM6SF2, GCKR, MBOAT7, and HSD17B13 play pivotal roles in NASH susceptibility. Lifestyle factors, particularly diet and exercise, amplify the genetic influence on NASH risk.
Understanding these genetic foundations is essential for risk assessment and tailored treatment strategies. To learn more about the intricate world of NASH genetics, download the full report below.