NAFLD or NASH

NAFLD or NASH

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Tags: Webinar NASH genetics

Webinar: An insider’s view on drug development in NASH

If you missed our live webinar, you can catch up on the discussion about the NASH therapy landscape by watching the video recording.

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Episode 61

Alnylam's Josh Friedman on developing precision medicines for the silent killer NASH/NAFLD

NAFLD or NASH research

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MAESTRO Clinical Trial

NAFLD or NASH research

Archived

  • Referral study
  • Ethically approved
  • Study site visit necessary
  • Commercial study
  • Sponsored
  • Data transferred outside Sano
  • Clinical Trial
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Insights & Information

NAFLD or NASH Prevalence

NAFLD affects approximately 1 in 4 people on a global scale.

NAFLD is highly prevalent on a global scale, but the highest rates are reported in South America and the Middle East, followed by Asia, the USA and Europe. [1]

Genetics

Genetically, NAFLD is complex, although it does have a consistent association with one gene PNPLA3, in European populations. Researchers are calling for further studies to investigate the genetics of NAFLD in diverse populations. [2]

The heritability of NAFLD or NASH is medium - 20% - 70% [3]

Main Symptoms

aching pain in the top right of the tummy
extreme tiredness
unexplained weight-loss
weakness

Early stage NAFLD is usually symptom-less and will only become apparent if diagnosed during tests carried out for another reason. Patients with NASH (a more advanced form of NAFLD) can sometimes experience the above symptoms. [4]

Impacts

Development of NAFLD is closely linked to lifestyle factors, including poor diet and lack of regular exercise. There is currently no drug therapy available for treatment of NAFLD. [5]

It’s estimated that the more advanced form of NAFLD, NASH, will be the most common reason for liver transplants in the USA by 2030. [6]

Resources for advice

These are the best resources we've found so far on managing and learning about NAFLD or NASH . Please let us know if you have other and we'll add them to the list!

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